Driving Routes to the Boston Cambridge Region
From Connecticut, New York City and points south, take I-95 north, to I-93 north, which will take you into the heart of Boston.
From western and central Massachusetts, upstate New York and points west, pick up I-90 east and take it directly into Boston.
From inland New Hampshire, Vermont and points north, take I-93 south directly into Boston.
From coastal Maine, coastal New Hampshire and the Maritimes of Canada, take I-95 south, and pick up I-93 south into Boston.
From Cape Cod, take U.S. Route 6 west, to Mass Route 3 north, to I-93 north into Boston.